There are currently some biomarkers that can accurately identify NPSLE and exclude non‐neuropsychiatric SLE, such as serum interleukin (IL)‐6,79 cerebrospinal fluid (CSF) IL‐6136 and immunoglobulin (Ig) G and/or IgM isotypes serum anti‐β2‐glycoprotein I (β2GPI) antibodies.137. Here, CD40LG is linked to systemic lupus erythematosus.