TDO2 and metabolic dysfunction-associated steatotic liver disease: In addition, Curcumin (an inhibitor of H3K27ac)‐induced decrease in TDO2 mRNA and protein levels were observed in a dose‐dependent manner (Figure 2H,I), further confirming that H3K27ac enhancers were important regulatory elements that regulated the hub target gene of TDO2 in the pathological process of MASLD.