SMAD4 and familial pancreatic carcinoma: Notably, pancreatic cancer exhibits recurrent mutations in key genes such as KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1 [8]. Additionally, other mutations have been observed in known oncogenes, DNA damage repair genes, and chromatin modification genes at slightly higher false discovery rates [8].