ROC analysis of immunological molecules in serum and CSF showed that the expression levels of IL-4, IFN-α, IFN-γ, IL-6, TNF-α, CCL4, CCL11, and VEGF exhibited high sensitivity and specificity in distinguishing between brain inflammation and brain tumor groups (p < 0.05) (Table 1). Here, CCL4 is linked to brain inflammatory disease.