ANXA5 and systemic lupus erythematosus: In the current study, we systematically analyzed the levels of circulating EVs from different cell types, such as LEVs, REVs, PEVs, or EEVs, and procoagulant Annexin V+ EVs, using flow cytometry, to determine the potential involvement of circulating EVs in pathogenesis of PAH in SLE patients.