In univariate logistic regression analyses, the levels of LEVs (>12023 events/μL), PEVs (>4882 events/μL), REVs (>4388 events/μL), EEVs (>569 events/μL), Annexin V+EVs (>46698 events/μL), and Annexin V+REVs (>1597 events/μL), as well as RBC-SD, RBC-CV, UA, positive anti-nRNP antibody and serositis were risk factors of PAH. The gene discussed is ANXA5; the disease is pulmonary arterial hypertension.