ANXA5 and systemic lupus erythematosus: All single-labeled EVs (LEVs, PEVs, REVs, EEVs and Annexin V+ EVs), and the dual-labeled EVs (Annexin V+ REVs) were significantly increased in SLE-PAH group as comparted to those in SLE-non-PAH group (Figure 2), suggesting the potential role of circulating EVs in PAH.