When we compared all circulating EVs among SLE patients with or without PAH, and healthy controls, we found significantly increased plasma levels of LEVs (CD45+LEVs), PEVs (CD41a+PEVs), REVs (CD235a+REVs), EEVs (CD144+EEVs), and Annexin V+EVs in SLE patients with or without PAH as compare to healthy controls (Figures 2A–E). This evidence concerns the gene ANXA5 and pulmonary arterial hypertension.