Interestingly, the plasma levels of Annexin V+EVs, REVs, and Annexin V+ REVs were elevated in SLE-PAH patients with inactive/mild SLE activities; while the SLE-PAH patients with moderate/high SLE activities have increased plasma levels of LEVs, PEVs, REVs, Annexin V+EVs, and Annexin V+ REVs (Table 4; Figure 3). This evidence concerns the gene ANXA5 and systemic lupus erythematosus.