HDM activates airway epithelial cells via Toll-like receptor (TLR), leading to NF-κB activation and secretion of pro-inflammatory cytokines, such as IL-6 and IL-1β (4), and also activates NLRP3 to promote HDM-induced inflammatory response in allergic asthma (5, 6). The gene discussed is NFKB1; the disease is allergic asthma.