TP63 variants are associated with 6 overlapping clinical phenotypes - ectrodactyly-ectodermal dysplasia clefting (EEC), ankyloblepharon-ectodermal defects-cleft lip/palate (AEC), limb-mammary syndrome (LMS) and acro–dermato–ungual–lacrimal–tooth (ADULT) syndromes, as well as split-hand/foot malformation type 4 (SHFM4) and non-syndromic cleft lip (NSCL) (16, 23). This evidence concerns the gene TP63 and split hand-foot malformation 4.