It is interesting to note that among these 15 genes, 5 genes (DNHD1, FOXRED1, SIGMAR1, SNHG17, and TRIM16) were restored by HKT administration (Figures 6B, C, 8F), providing the possibility for the general efficacy of this drug on a variety of types of depression including TRD (158; treatment-resistant depression). Here, SIGMAR1 is linked to major depressive disorder.