LRRK2 and Parkinson disease: It has been generally accepted that leucine-rich repeat kinase 2 (LRRK2) mutations are a cause of inherited PD (Paisán-Ruíz et al., 2004; Zimprich et al., 2004), and the LRRK2 protein are one of the central molecules in PD researches (Cookson, 2015; Domingos et al., 2019; Lee et al., 2012).