However, the Breast Cancer Linkage Coalition (BCLC) has previously reported that the relative risk of PC in men with a family of pathogenic BRCA2 mutations is 2.9-4.8, and in certain subgroups, such as those aged 65 years<, the lifetime risk is approximately 20%, with a relative risk of 7.3. The gene discussed is BRCA2; the disease is breast cancer.