Lu et al. (2016) emphasized that coumarin–sulfonamide hybrids are effective as COX-2 inhibitors and induce apoptosis in cancer cells. Chen et al. (2023) indicated that 3-(coumarin-3-yl)-acrolein derivatives may lead to mitochondria-dependent apoptosis by inhibiting the PI3K/AKT signaling pathway. Koparde et al. (2018) reported that coumarin–maltol hybrids can induce DNA double-strand breaks in cancer cells. Lu et al. (2016) demonstrated that coumarin–sulfonamide hybrids, which act as COX-2 inhibitors, induce apoptosis in cancer cells and suppress metastasis. Here, PIK3CA is linked to cancer.