BAX and ovarian cancer: Activation of procaspases 3 and 9, downregulation of Bcl-2 protein, and upregulation of Bax (Bcl-2-associated X protein) protein also arresting the cell cycle at the G0/G1 phase in the ovarian cancer cell line were the identified mechanisms for a new coumarin compound, pulchrin A (Nordin et al., 2016).