CXXC finger protein 4 (CXXC4) is the negative regulatory factor of Wnt/β-catenin signaling pathway and is also able to suppress the activation of NF-κB and p38 mitogen activated protein kinase (MAPK) pathway (Han et al., 2017; Li et al., 2020c), which are involved in the chronic inflammatory responses of TB (Holscher et al., 2020; Poladian et al., 2023). The gene discussed is CXXC4; the disease is tuberculosis.