CXXC finger protein 4, is a tumor suppressor regulated by EZH2, functions to inhibit both Wnt/β-catenin signaling pathway by interacting with Disheveled and MAPK/ERK signaling by binding to MEK1, and can stimulate the transcription of GDF15 (growth differentiation factor 15) to activate apoptosis Han et al. (2017) and improve the proliferation of CD3+ T Cells through ELK1‐mediated regulation of ERK1/2 axis Li et al. (2020b). This evidence concerns the gene MAP2K1 and neoplasm.