The mageb16 gene, most significantly downregulated in this study, usually encodes tumor antigens and is also a DE gene or protein in many genomics research results such as gastric cancer (Zaragoza-Huesca et al., 2022), colorectal cancer (Juhari et al., 2021), bladder cancer (Liu et al., 2016), and other tumor diseases, as well as feline abdominal virus infection (Shuid et al., 2015), indicating that it may play an important role in tumorigenesis. The gene discussed is MAGEB16; the disease is colorectal cancer.