Multivariate logistic regression analysis was performed on the gender, age, smoking, and drinking history, histopathologic types, serum tumor markers, tumor long diameter, nodule types, and TNM stage of NSLCL patients, and the results showed that EGFR mutations were correlated with gender (odds ratio [OR] = 0.359, 95% confidence interval [CI]: 0.237–0.543; P< 0.001), smoking history (OR = 1.714, 95% CI: 1.126–2.607; P = 0.012), histopathological type (OR = 0.064, 95% CI: 0.015–0.274; P< 0.001), and nodule types (OR = 1.974, 95% CI: 1.096–3.556, P = 0.023). Here, EGFR is linked to neoplasm.