Multivariate logistic regression analysis was performed on the gender, age, smoking, and drinking history, histopathologic types, serum tumor markers, tumor long diameter, nodule types, and TNM stage of NSLCL patients, and the results showed that KRAS mutations were correlated with gender (OR = 0.029, 95% CI: 0.007–0.117; P< 0.001) and tumor long diameter (OR = 1.120, 95% CI: 1.025–1.223; P = 0.012). The gene discussed is KRAS; the disease is neoplasm.