EGFR and adenocarcinoma: In the IA subtypes, EGFR mutations were negatively associated with solid-predominant adenocarcinoma in Model 1, Model 2, and Model 3 (P< 0.001, P< 0.001, P = 0.004, respectively) and positively associated with lepidic-predominant adenocarcinoma in Model 1 and Model 2 (P = 0.033, P = 0.023, respectively).