Overall, our work demonstrated that the probability of EGFR mutations was positively correlated with women, non-smokers, lung adenocarcinoma, and the IA subtype of adenocarcinoma, while EGFR mutations were negatively correlated with solid nodule, the MIA subtype of adenocarcinoma, and the solid-predominant adenocarcinoma subtype of IA. Here, EGFR is linked to lung adenocarcinoma.