FBXW7 and Global developmental delay: Developmental delay, hypotonia, and impaired language (DEDHIL, OMIM: #620012) is a rare autosomal dominant disorder caused by heterozygous variants in the FBXW7 gene, which has been shown to regulate cell cycle progression, cell signaling, and development via the ubiquitin proteasome system (UPS) targeting cyclinE1/2, Notch, c-Jun and other substrates for degradation (Stephenson et al., 2022; De La Cova, 2023).