Among the numerous intracellular signalling pathways that WDR26 is involved in regulating, alterations in Wnt and PI3 K have been implicated in neurodevelopmental, neurodegenerative and neuropsychiatric disorders, and dysfunction in these pathways has also been associated with diseases such as cardiovascular, renal, pulmonary, allergic, bone and oral diseases (8, 9). This evidence concerns the gene WDR26 and mouth disorder.