For example, stromal cells such as CAFs in PCa TME promote therapy resistance and CRPC development by triggering PCa cell EMT through secreting cytokines such as TGF-beta, by reprogramming CAFs themselves from iCAFs to SPP1+ MyCAFs, or by secreting the ECM proteoglycan glucosamine to enhance intracrine androgen production (Figure 6). The gene discussed is SPP1; the disease is posterior cortical atrophy.