SOAT1 and adenocarcinoma: In adenocarcinoma cells, inflammatory signaling (with enrichment of response gene signatures including IFN-alpha, IFN-gamma, JAK/STAT and TNF-alpha) precedes NEPC, and JAK/STAT upregulation coincides with the onset and progression of various cellular states and phenotypes such as basal-luminal mixed lineage, EMT and transition to NEPC [70].