In support of the latter evidence, Hayashi et al. (8) reported a peculiar case of uterine sarcoma with the pathogenic BRCA2 p.(Ile2675Val) variant (present in the ClinVar database with 17 entries) with low variant allele frequency (5%) identified in tumor-only comprehensive genomic profiling that was then confirmed to be germline in matched tumor-normal comprehensive genomic profiling. The gene discussed is BRCA2; the disease is neoplasm.