SHANK3 and premenstrual tension: The neurobehavioral phenotype of PMS is typically caused by haploinsufficiency of the SHANK3 gene [1, 21, 25], encoding a scaffolding protein located in the postsynaptic density of glutamatergic synapses, which plays a crucial role in the formation and management of dendritic spines and excitatory synapses [26].