MMP2 and central nervous system cancer: Cao et al. reported that Malat1 expression was significantly decreased in glioma specimens, and overexpression of Malat1 suppressed glioma cell viability through the Malat1/miRNA-155/FBXW7 axis [40]; Han et al. also demonstrated the tumor-suppressive function of MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling [41].