Taken together, these data revealed that in the infected mice, knockout of Malat1 gene upregulated miRNA-96 expression, leading to a reduction of Smad7 expression, indicating that the Malat1-mediated suppression of the schistosomiasis HF occurs through the Malat1/miRNA-96/Smad7 axis. Here, SMAD7 is linked to hydrops fetalis.