Recently, a missense variant in TRPC5 has been identified (NM_012471.2:c.523C>T, p.(Arg175Cys)) in patients with an X-linked disorder presenting as intellectual disability and/or autism [17], and disruption of the TRPC5 gene has been shown to cause obesity, behavioral problems such as anxiety, reduced social interactions, outbursts of aggression and, in mothers, postpartum depression [18]. This evidence concerns the gene TRPC5 and obesity due to melanocortin 4 receptor deficiency.