Risk genes for developmental delay, including CTCF, SATB1, ARID2, SMAD4, H3-3A, SOX2, and PPP2CA, were coherently expressed during the transition phase from neuroblasts to fetal inhibitory neurons around the fetal second trimester, suggesting a heightened risk of disorder at this stage of neural development. The gene discussed is H3-3A; the disease is Global developmental delay.