In contrast to findings in “classical dilated heart failure” where expression of NCX1 and CaMKIIδ are typically upregulated, heart failure in FA was associated with the decreased expression in NCX1 and CaMKIIδ in both males and females which indicates that classical HF treatment regime may not work for cardiomyopathy in FA, and more detailed investigation on this topic is required. This evidence concerns the gene SLC8A1 and hydrops fetalis.