Our study also reveals that in contrast to pressure-overload-induced heart failure (HF) and dilated cardiomyopathy where expression of sodium-calcium exchanger (NCX) and calmodulin-dependent protein kinase II delta (CaMKIIδ) are typically upregulated, cardiomyopathy in FA was associated with decreased expression in NCX and CaMKIIδ in both males and females. The gene discussed is TLX2; the disease is Friedreich ataxia.