We also observed increased (MMP-1, IL-18R1, MMP-1, HGF, OSM, Flt3L, EN-RAGE and CD40) and decreased (LAP TGF-beta-1, TNFSF14, TNFRSF9, CD8A, SIRT2, ST1A1 and STAMBP) protein release of several inflammatory mediators that currently lack a known association to UTI. This evidence concerns the gene IL18R1 and bacterial urinary tract infection.