INS and type 1 diabetes mellitus: The peptides can be conjugated onto HA by hydrolysable linkers (hSAgAs) or stable click chemistry linkers (cSAgAs) and delivered to the body via the multivalent, soluble and linear form.478 Investigators combined a hybrid insulin peptide and a mimotope as SAgAs and showed efficacy for T1D prevention.478 The group also reported that SAgAs can direct the response of epitope-specific T cells.479