By analyzing transcriptional markers, Solé et al. pointed out that the production of FOXP3-IL-10+ Treg1 cells originates from the Tfh cells via BLIMP1-dependent manner and furthermore confirmed the important role of the pMHC therapy method for autoimmune diseases.453 Vacchio et al. reported transcription factor Thpok was necessary for driving Bcl6 and Maf expression to promote differentiation from CD4+T cells to Tfh cells.454. Here, CD4 is linked to autoimmune disease.