Researchers use DCs loading mouse thyroglobulin to prevent the development in experimental autoimmune thyroiditis.559 In a phase 1b trial, the engineering tolDCs loading with myelin proteins and aquaporin-4 (AQP4) to treat MS patients and induced increase of Tr1 and IL-10 levels successfully without serious adverse events and therapy-related reactions.560 VitD3-antigen-specific tolDCs pulsed with MOG40-55 ameliorated EAE.561,562 OVA-pulsed DCs activated by LPS also alleviated inflammation in OVA-sensitized mice.563. The gene discussed is AQP4; the disease is autoimmune thyroid disease.