CD8A and type 1 diabetes mellitus: Tsai et al. utilized NPs to deliver T1D-related peptides-MHC complexes for monospecific resistance of the T1D development, and demonstrated that pMHC can expand the memory-like and autoregulatory CD8+ T cells.460 NPs coated with pMHC can blunt T1D progression and restore normoglycemia in diabetic animals.460