TNF and rheumatoid arthritis: The related inflammatory genes were effectively silenced in the macrophage stimulation culture test and mouse RA model.307 Besides, Different nanomaterial carriers are used to deliver the siRNA targeting TNF-α including Lipid-polymer hybrid nanoparticles (LPNs),308 degradable cationic polymer (PDAPEI),309 sheddable PEGylated solid-lipid nanoparticle,310 folate-PEG-chitosan DEAE nanoparticle,311 etc.