Besides, these engineering tolDCs can induce antigen-specific Tr1 and prevent the development of T1D in NOD mice.558 Gudi et al. engineered DC to express B7.1wa, PD-L1, HVEM-CRD1 or multi-ligand combination which can prevent the CD4+ T cells proliferation and related inflammatory cytokines secretion. This evidence concerns the gene CD274 and type 1 diabetes mellitus.