CD27 and neoplasm: Finally, we identified two interaction axes between clusters of the same cellular compartment: first, the L-R pairing CD70-CD27 in the tumor cell compartment [both in the autocrine mode of the two clusters T5_Cycling and T1_MYC (T5::T5 and T1::T1) and in a paracrine mode with the receiver clusters T4, T6 and T9_EMT], secondly, the COL6A2-ITGA1/B1 pairing between different sender and receiver clusters in the NHC compartment (Fig. 4B, I).