By using a more stringent false discovery rate (t-test: σ/σmax > 0.4, q < 1e-5), the number of concordantly hypermethylated genes in both species was reduced to 28 genes covering a network around cancer/T-cells related genes (e.g., CTLA4, ETS1) (Supplementary Data S2). The gene discussed is CTLA4; the disease is cancer.