Analysis of T-cell subtypes in SAHA-treated versus untreated PTCL revealed (i) a relative increase in the proportion of Cd8+ effector T-cells, (ii) of Cd4+ and Cd8+ naive T-cells, (iii) of NKT and NK cells, and (iv) an almost complete extinction of terminally exhausted T-cells in SAHA (Fig. 7B–D). Here, CD4 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.