CXCR4 and neoplasm: These include the CXCL12-CXCR4 axis with stromal NESC and FRC clusters and the CCL19-CCR7 and CXCL9-CXCR3 axes with FRC as senders; for all three signaling axes, different tumor/myeloid clusters such as T9/M0_EMT or T5/M3_Cycling represent the receiver cells (Fig. 4B–F).