Considering that the development of PTCL has been intimately linked to features of clonal hematopoiesis (CHIP) in both species61, it is intriguing to speculate that SMARCB1 plays a pathogenic role in differentiation processes in early hematopoietic cells leading to PTCL. This evidence concerns the gene STUB1 and mature T-cell and NK-cell non-Hodgkin lymphoma.