Among bHLH family proteins, ETS1, ETS2, ELF3 (E74‐Like Factor 3, a.k.a. ESE1), and EHF (ETS homologous factor, a.k.a. ESE3) play crucial roles in the EMT program and differentiation in various cancer cells (Saitoh, 2023; Suzuki et al., 2021). Here, ELF3 is linked to cancer.