Compared to the control group, the insulin group presented a higher proportion of important perinatal outcomes, even in the face of multidisciplinary monitoring and protocols recommended by the Brazilian Diabetes Society, the Brazilian Federation of Gynecology and Obstetrics, and the Ministry of Health, which suggests the need for early diagnosis and multidisciplinary monitoring so that in the case of GDM there is no need for insulin treatment. This evidence concerns the gene INS and diabetes mellitus.