CALR and cancer: Similarly, the ubiquitination levels of proteins such as CALR, CANX (related to endoplasmic reticulum protein folding), G3BP1 (related to stress particle formation), ARF4 (important molecules related to cancer processes), and GSTM3 (metabolites related to chemical carcinogenesis) were upregulated, but the differences were not significant (54, 55, 56).