Statistically significant longer doctor intervals were observed in patients who had localized vs. metastatic cancer stage, presence of more than two comorbidities, where GPs' didn't have access to laboratory diagnostic tests (CBC, CRP, urine, PSA) within their primary health care centre and when patients first presented with symptoms (reported symptoms at first presentation: dysuria, LUTS, abdominal pain). Here, KLK3 is linked to metastatic malignant neoplasm.