Further, such pathology is found in ~45% of frontotemporal dementia (FTD) cases, and is also observed in limbic-predominant age-related TDP-43 encephalopathy (LATE) and Alzheimer’s disease, suggesting TDP-43-mediated RNA dysregulation is a critical element in many neurodegenerative diseases (2, 3). This evidence concerns the gene TARDBP and frontotemporal dementia.