In summary, these findings demonstrate that the functional effects of plakoglobin on mutant p53 tumorigenic abilities may be cell context dependent as seen from the tumor suppressive (inhibition of invasion and/or migration) functions of plakoglobin on p53-R175H but not p53-R273H in H1299 cells, and on both p53-R175H and p53-R273H in SKOV-3 cells. Here, TP53 is linked to neoplasm.