TP53 and carcinoma: We have previously shown that plakoglobin interacts with endogenously expressed p53-WT and p53 mutants and that exogenous expression of plakoglobin in plakoglobin deficient and mutant p53 (e.g., R280K, R273H, S241F, S215R) expressing carcinoma cell lines of different origins restored p53 tumor suppressor activity in vitro [24–28].