In addition, although there is no direct evidence for this, a prediction can be made based on indirect evidence that describes the interaction between HSPG and cadherin [48–51]–Cdh11 can be a possible therapeutic target for cocaine addiction, which is not only one of the rDEGs of the HSPG biosynthetic process module (module 49), but also a well-known transmembrane proteins that mediate cell–cell adhesion in signaling. The gene discussed is CDH11; the disease is cocaine dependence.