Those who complained of Raynaud symptoms had lower serum concentrations of SMRP and FER (p<0.0001); arthralgia/arthritis was associated with lower KL-6, SMRP and FER (p = 0.0048, p = 0.0002 and p<0.0001, respectively); sclerodactyly and mechanic’s hands with lower FER (p = 0.0192 and p = 0.0364, respectively); elevated CK with lower SMRP, FER and IL-6 concentrations (p<0.0001, p = 0.0096 and p = 0.0004, respectively); myalgia with lower SMRP and FER concentrations (p = 0.0032 and p = 0.0191) and periungual erythema with lower SMRP values (p = 0.0110). This evidence concerns the gene IL6 and arthritic joint disease.