Like the pro-inflammatory cell function phenotype found in the HF diet group, genes associated with pro-inflammatory T cell subsets (Th1, Th17, etc.)such as Mpeg1, Lyz2, and Ctsh were upregulated, whereas Th2/Treg related genes such as Ccr4 and Ctla-2 were downregulated in the HF diet group. The gene discussed is CCR4; the disease is hydrops fetalis.