Literature examples of this in COVID-19 severity include a DOCK2 gene variant in East Asians (Namkoong et al., 2022) and frequent loss-of-function variants in IFNAR1 and IFNAR2 genes in Polynesian and Inuit populations, respectively (Bastard et al., 2022; Duncan et al., 2022). Here, IFNAR2 is linked to COVID-19.