This inhibition was mediated by down-regulating PTX3 through NF-κB and Wnt/β-catenin signaling pathways, which may be due to selective binding to one of the voltage-gated- Na+-channel subunits, Nav 1.5 (Kampo et al. 2019), which is over-expressed in BC and has a role in its progression (Brackenbury 2012). This evidence concerns the gene NFKB1 and breast cancer.