Furthermore, the venom reduced the expression of pro-inflammatory cytokines and downregulated key molecular markers associated with tumor development, including Ki-67, nuclear factor kappa-B (NF-κB), cyclooxygenase-2 (COX-2), B-cell lymphoma-2 (Bcl-2), and vascular endothelial growth factor (VEGF) as revealed by immunohistochemistry analysis (Al Asmari and Khan 2016). Here, PTGS2 is linked to neoplasm.