MPO and kidney disorder: Besides, recent reports with acute and severe hypouricemia (median SUA was 0.2 mL/dL) indicate that UA reduction may improve endothelial function, blood pressure, and arterial stiffness and enhance antioxidant activity due to decreased myeloperoxidase activity, suggesting that hypouricemia may not always lead to a kidney disease based on impaired endothelial function [26, 27].