These transcription factors, such as hypoxia-inducible factor (HIF), factor inhibiting HIF-1 (FIH-1), and nuclear factor-κB (NF-κB), not only regulate the expression of genes involved in cell survival and metabolism but also modulate various aspects of tumor biology, such as angiogenesis, immune evasion, and therapeutic resistance [7, 137]. The gene discussed is HIF1AN; the disease is neoplasm.