Pharmacologicalinhibition of NQO1 led to decreased BQA-induced Hsp90 inhibition andtoxicity to human cancer cells whereas genetic overexpression of NQO1led to increased BQA-induced toxicity.52 The role of NQO1 in the bioreduction of quinone-containing antitumoragents such as mitomycin C,56 aziridinylbenzoquinonesincluding RH1,57 β-lapachone58 and streptonigrin59 has been well characterized.60 Here, NQO1 is linked to cancer.