TGFBR1 and cancer: Among the small portion of specific 138 DEGs (Supplementary file 1) that were conserved from exposed iPSCs to derived PGCLCs, several (12.32%) (Cdkn1a, Ccnd2, Plk2, Tgfbr1, Gadd45g, Lck, Ltbr, Mad2l1, Ap3m2, Ctsz, Tcirg1, Gusb, Id2, Lefty2, Gstm7, Acsl1, Slc39a14) were involved in cell cycle and apoptosis pathways which could potentially be linked to cancer development (Figure 7—figure supplement 1).