When combined with laser irradiation, it can not only destroy tumor tissue but also ameliorate the immunosuppressive phenomena of the tumor microenvironment by boosting PD1 expression, biomineralizing gold nanopar-ticles (Wang et al., 2021) induce the expression of ClyA under near-infrared laser irradiation to kill tumor cells. This evidence concerns the gene PDCD1 and neoplasm.