S100A8 and gastric cancer: CagA is a particularly significant virulence factor of H. pylori as it is closely associated with the development of GC (Hatakeyama, 2014; Tojjari et al., 2024; Huang et al., 2018; Jenke et al., 2024; Long et al., 2024; Yuan et al., 2024; Asahi et al., 2000; Higashi et al., 2002; Conradi et al., 2012; Fajardo et al., 2013).