Upregulation of GRB7 has been observed in breast cancer, bladder cancer, ovarian cancer, esophageal cancer, and GC (Wang et al., 2010; Zheng et al., 2020; Gotovac et al., 2020; Pei et al., 2022; Nadler et al., 2010). This evidence concerns the gene GRB7 and esophageal cancer.