GRB7 and cancer: The ERK signaling is one of the important pathways associated with proliferation and migration in various cancers (Roskoski, 2017; Chen et al., 2021; Savoia et al., 2019; Zhang et al., 2022), through western blot assay, we found that the levels of p-ERK in AGS and MGC-803 cells were significantly increased by GRB7 overexpression (Figure 6A).