Previous studies have demonstrated that obesity causes a persistent low-grade inflammation in the body and the production of pro-inflammatory factors, such as TNF-α, IL-1β, IL-6, etc., which inhibit skeletal muscle cell proliferation and differentiation, promote skeletal muscle protein degradation, and induce apoptosis, reducing skeletal muscle mass through various signaling pathways (38, 39). The gene discussed is TNF; the disease is obesity disorder.