The most upregulated core genes in the 3W animals included Nr1d1, Sucnr1, and Trib3. Interestingly, Nr1d1, a nuclear receptor REV-ERB-α, is involved in molecular clock mechanisms and has been linked to metabolism, obesity, and diabetes [47]. The gene discussed is NR1D1; the disease is obesity due to melanocortin 4 receptor deficiency.