Future research will need to examine AKI models of different etiologies and severity and follow up longer to examine whether different types and severity of AKI have different Aldh1a2 responses and whether AKI-to-CKD transition is accompanied with repressed Aldh1a2 expression, and if so, whether such changes in Aldh1a2 expression play a causal role in AKI-to-CKD transition. The gene discussed is ALDH1A2; the disease is acute kidney injury.