To further examine how ALDH1A2 mRNA expression in PECs changes in CKD patients, we assessed the Kidney Interactive Transcriptomics snRNA-seq analysis of patients with mild to moderate diabetic nephropathy and end-stage autosomal dominant polycystic kidney disease (ADPKD), and the Susztak Lab snRNA-seq analysis of kidney tissues from patients with CKD associated with diabetes or hypertension (Table 1) [13–15]. Here, ALDH1A2 is linked to chronic kidney disease.