ALDH1A2 and focal segmental glomerulosclerosis: Recent scRNA-seq studies have shown that Aldh1a2 mRNA expression in PECs changes differentially in different mouse glomerular disease models, ranging from a substantial increase in anti-GBM glomerulonephritis (Figures 2C, F), marked repression in CKD (Figure 3A), and moderate induction in mice undergoing ischemia-reperfusion-induced AKI (Figure 3D), to a moderate repression in mouse models of FSGS manifesting nephrotic syndrome (Supplementary Figure S1).