Accordingly, the thrombolytic ability of FGFCs plays a major role in other pathophysiological conditions since the plasminogen/plasmin system is a fundamental process for pericellular proteolysis, which is widely involved in several biological processes such as embryogenesis, angiogenesis, tissue remodeling, tumor growth/metastasis and wound healing (Castellino and Ploplis, 2005; Danø et al., 2005; Lund et al., 2006; Hasumi and Suzuki, 2021). This evidence concerns the gene PLG and neoplasm.