DMC1, RAD51, RAD51 regulators, and RAD51 mediators in POI: Of the three reproductive diseases focused on in this review, POI has the largest data set including seven missense variants (codon change resulting in variant amino acid), three frameshift mutations (deletion of one nucleotide), four premature stop codons and one aberrant splicing resulting in a missense variant. The gene discussed is RAD51; the disease is reproductive system disorder.