It remains unknown if the RAD51 paralog mutants identified in RAD51B, XRCC2, XRCC3 and SWS1 (required for stability of the RAD51-paralog containing complex with SWSAP1) which could remain proficient for HR, may have a separate importance in these female reproductive diseases through inhibition of other protein activities. Here, ZSWIM7 is linked to female reproductive system disorder.