Similarly, we observed seizure control in specific GESs, including Dravet syndrome (mainly caused by SCN1A mutations) and LGS, which can involve mutations in CDKL5, DNM1, STXBP1, or SCN2A genes. Here, CDKL5 is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.