Similarly, we observed seizure control in specific GESs, including Dravet syndrome (mainly caused by SCN1A mutations) and LGS, which can involve mutations in CDKL5, DNM1, STXBP1, or SCN2A genes. The gene discussed is STXBP1; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.