In addition, exosomes secreted from the osteosarcoma cell line can induce M2 polarizations of TAMs through the regulation of the expression of T-cell immunoglobulin and mucin domain (Tim) family proteins, particularly Tim-3, which promotes the migration, invasion, epithelial-mesenchymal transition (EMT), and lung metastasis of osteosarcoma cells (44). This evidence concerns the gene HAVCR2 and osteosarcoma.