CD8A and hemophagocytic syndrome: In addition to consolidated HLH biomarkers encoded by the 2004 diagnostic criteria, some authors have identified an expansion of CD38high/HLA-DR+CD8+ T cells in HLH (84, 85), that relates to an increase of sIL-2R as an expression of T cell activation (86) which has also been described in forms classified as VL-HLH (87). However, this lymphocyte population seems to show different degrees of expansion in all forms of VL which would make it unsuitable for discriminating between VL and HLH (unpublished data).